Abstract
In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.
Original language | English (US) |
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Pages (from-to) | 206-210 |
Number of pages | 5 |
Journal | Journal of medical primatology |
Volume | 20 |
Issue number | 4 |
State | Published - Jun 1991 |
ASJC Scopus subject areas
- Animal Science and Zoology
- General Veterinary