@article{80b2a8b489384512bb24938d10204504,
title = "Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans",
abstract = "To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P =. 01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10-4), as was one 81-kb haplotype (adjusted P =. 0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.",
keywords = "Tim 1, hepatitis C virus, human genetics",
author = "Genevieve Wojcik and Rachel Latanich and Tim Mosbruger and Jacquie Astemborski and Kirk, {Gregory D.} and Mehta, {Shruti H.} and Goedert, {James J.} and Kim, {Arthur Y.} and Seaberg, {Eric C.} and Michael Busch and Thomas, {David L.} and Priya Duggal and Thio, {Chloe L.}",
note = "Funding Information: Financial support. This project was supported by the National Institutes of Health (NIH; grant number R01 DA013324 to D. L. T.). REVELL is funded by the NIH (grant number RO1-HL-076902). ALIVE is funded by the NIH (grant numbers DA04334 to G. D. K., DA12568 to S. H. M.). The WIHS is funded by the NIH (grant numbers UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant number UO1-HD-32632). WIHS is cofunded by the National Cancer Institute, the National Institute on Drug Abuse, the National Institute on Deafness and Other Communication Disorders, and the National Center for Research Resources (UCSF-CTSI grant number UL1 RR024131). MHCS II is supported in part by the Intramural Research Program of the National Cancer Institute. A. Y. K. is funded by the NIH (grant numbers U19-AI-066345, R01-DA031056, and R01-DA-033541).",
year = "2014",
doi = "10.1093/infdis/jit444",
language = "English (US)",
volume = "209",
pages = "355--359",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",
}