Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States

P. K. Sue; N. Pisanic; C. D. Heaney; T. Mixson-Hayden; S. Kamili; K. Nelson; K. B. Schwarz; M. Forman; A. Valsamakis; J. Ticehurst; W. Karnsakul

doi:10.1111/tid.12366

Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States

P. K. Sue, N. Pisanic, C. D. Heaney, T. Mixson-Hayden, S. Kamili, K. Nelson, K. B. Schwarz, M. Forman, A. Valsamakis, J. Ticehurst, W. Karnsakul

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6 Scopus citations

Abstract

Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.

Original language	English (US)
Pages (from-to)	284-288
Number of pages	5
Journal	Transplant Infectious Disease
Volume	17
Issue number	2
DOIs	https://doi.org/10.1111/tid.12366
State	Published - Apr 1 2015

Keywords

Hepatitis E virus
Liver transplantation
Viral diagnostics

ASJC Scopus subject areas

Infectious Diseases
Transplantation

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10.1111/tid.12366

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Sue, P. K., Pisanic, N., Heaney, C. D., Mixson-Hayden, T., Kamili, S., Nelson, K., Schwarz, K. B., Forman, M., Valsamakis, A., Ticehurst, J., & Karnsakul, W. (2015). Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States. Transplant Infectious Disease, 17(2), 284-288. https://doi.org/10.1111/tid.12366

Sue, PK, Pisanic, N , Heaney, CD, Mixson-Hayden, T, Kamili, S, Nelson, K, Schwarz, KB, Forman, M, Valsamakis, A, Ticehurst, J & Karnsakul, W 2015, 'Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States', Transplant Infectious Disease, vol. 17, no. 2, pp. 284-288. https://doi.org/10.1111/tid.12366

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abstract = "Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.",

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AU - Mixson-Hayden, T.

AU - Kamili, S.

AU - Nelson, K.

AU - Schwarz, K. B.

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AB - Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.

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Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States

Abstract

Keywords

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