Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations

Jesse D. Sutton; Jae Hyoung Lee; Karen Howard; Katelyn S. Quartuccio; Christopher McCoy; Alok Gupta; Judianne C. Slish; Drew W. Engers; Anurag N. Malani; Sara M. Karaba; Kelly E. Pillinger; Pranita D. Tamma; Timothy C. Jenkins

doi:10.1093/ofid/ofaf298

Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations

Jesse D. Sutton
, Jae Hyoung Lee
, Karen Howard
, Katelyn S. Quartuccio
, Christopher McCoy
, Alok Gupta
, Judianne C. Slish
, Drew W. Engers
, Anurag N. Malani
, Sara M. Karaba
, Kelly E. Pillinger
, Pranita D. Tamma
, Timothy C. Jenkins

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9–15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.

Original language	English (US)
Article number	ofaf298
Journal	Open Forum Infectious Diseases
Volume	12
Issue number	6
DOIs	https://doi.org/10.1093/ofid/ofaf298
State	Published - Jun 1 2025

Keywords

antimicrobial stewardship
antimicrobial treatment
duration of therapy
gram-negative bacteremia
gram-negative bloodstream infection

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofaf298

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Sutton, J. D., Lee, J. H., Howard, K., Quartuccio, K. S., McCoy, C., Gupta, A., Slish, J. C., Engers, D. W., Malani, A. N., Karaba, S. M., Pillinger, K. E., Tamma, P. D., & Jenkins, T. C. (2025). Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations. Open Forum Infectious Diseases, 12(6), Article ofaf298. https://doi.org/10.1093/ofid/ofaf298

Sutton, JD, Lee, JH, Howard, K, Quartuccio, KS, McCoy, C, Gupta, A, Slish, JC, Engers, DW, Malani, AN, Karaba, SM, Pillinger, KE, Tamma, PD & Jenkins, TC 2025, 'Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations', Open Forum Infectious Diseases, vol. 12, no. 6, ofaf298. https://doi.org/10.1093/ofid/ofaf298

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abstract = "Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9{\textendash}15); 59\% were treated for >10 days. There was marked variability in treatment durations across hospitals.",

keywords = "antimicrobial stewardship, antimicrobial treatment, duration of therapy, gram-negative bacteremia, gram-negative bloodstream infection",

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doi = "10.1093/ofid/ofaf298",

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AU - Quartuccio, Katelyn S.

AU - McCoy, Christopher

AU - Gupta, Alok

AU - Slish, Judianne C.

AU - Engers, Drew W.

AU - Malani, Anurag N.

AU - Karaba, Sara M.

AU - Pillinger, Kelly E.

AU - Tamma, Pranita D.

AU - Jenkins, Timothy C.

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AB - Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9–15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.

KW - antimicrobial stewardship

KW - antimicrobial treatment

KW - duration of therapy

KW - gram-negative bacteremia

KW - gram-negative bloodstream infection

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Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations

Abstract

Keywords

ASJC Scopus subject areas

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