Abstract
Modifications to Fried’s frailty phenotype (FFP) are common. We evaluated a self-reported modified frailty phenotype (Mod-FP) used among people with HIV (PWH). Among 522 PWH engaged in two longitudinal studies, we assessed validity of the four-item Mod-FP compared with the five-item FFP. We compared the phenotypes via receiver operator characteristic curves, agreement in classifying frailty, and criterion validity via association with having experienced falls. Mod-FP classified 8% of PWH as frail, whereas FFP classified 9%. The area under the receiver operator characteristic curve for Mod-FP classifying frailty was 0.93 (95% CI 5 0.91–0.96). We observed kappa ranging from 0.64 (unweighted) to 0.75 (weighted) for categorizing frailty status. Both definitions found frailty associated with a greater odds of experiencing a fall; FFP estimated a slightly greater magnitude (i.e., OR) for the association than Mod-FP. The Mod-FP has good performance in measuring frailty among PWH and is reasonable to use when the gold standards of observed assessments (i.e., weakness and slowness) are not feasible.
Original language | English (US) |
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Pages (from-to) | 158-170 |
Number of pages | 13 |
Journal | Journal of the Association of Nurses in AIDS Care |
Volume | 34 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1 2023 |
Keywords
- HIV and aging
- feasibility
- frailty phenotype
- people with HIV
- validity
ASJC Scopus subject areas
- Advanced and Specialized Nursing