Validity and responsiveness of a brief, asthma-specific quality-of-life instrument in children with acute asthma

Marc H. Gorelick, David C. Brousseau, Molly W. Stevens

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Objective: To test the validity and short-term responsiveness to change of a pediatric, asthma-specific, health-related quality-of-life (HRQL) instrument. Methods: Children 2 years and older treated in the emergency department (ED) for acute asthma were eligible for this prospective cohort study. A 10-item instrument, the Integrated Therapeutics Group Child Asthma Short Form (ITG-CASF), was administered at the time of the ED visit and again 14 days later (via telephone). At the follow-up call, parents were also asked about the child's current overall asthma status, missed school or limited activities, and persistence of asthma symptoms. Results: A total of 121 children were enrolled (mean age, 7.9 years), and follow-up was complete for 96 (79%). Mean ± SD ITG-CASF scores at follow-up were significantly higher among children reported to have improved overall (61.8 ± 19.6) than those not improved (41.9 ± 21.2), and there was a significant correlation between ITG-CASF score at follow-up and the number of days of school missed or limited activities (r = -0.45; 95% confidence interval [CI], -0.24 to -0.66). There was also a significant difference in improvement in ITG-CASF score from ED visit to follow-up among those improved (13.7-point improvement) compared with those not improved (3.3-point improvement; difference = 10.4; 95% CI, 1.2 to 19.5). The effect size was 0.68, indicating a large responsiveness to change. Conclusions: The ITG-CASF is a valid and responsive measure of HRQL in children with acute asthma and may be a useful outcome measure in evaluating ED treatment.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalAnnals of Allergy, Asthma and Immunology
Issue number1
StatePublished - Jan 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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