Validation of 19f‐magnetic resonance determination of myocardial blood volume

Gerald A. Rottman; Robert M. Judd; Frank C.P. Yin

doi:10.1002/mrm.1910340421

Validation of ¹⁹f‐magnetic resonance determination of myocardial blood volume

Gerald A. Rottman, Robert M. Judd, Frank C.P. Yin

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of ¹⁹F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and ¹²⁵I‐albumin. Measurement of myocardial vascular volume by ¹⁹F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.

Original language	English (US)
Pages (from-to)	628-631
Number of pages	4
Journal	Magnetic resonance in medicine
Volume	34
Issue number	4
DOIs	https://doi.org/10.1002/mrm.1910340421
State	Published - Oct 1995
Externally published	Yes

Keywords

NMR
blood
myocardium
perfluorochemical

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/mrm.1910340421

Cite this

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title = "Validation of 19f‐magnetic resonance determination of myocardial blood volume",

abstract = "The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of 19F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and 125I‐albumin. Measurement of myocardial vascular volume by 19F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.",

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T1 - Validation of 19f‐magnetic resonance determination of myocardial blood volume

AU - Rottman, Gerald A.

AU - Judd, Robert M.

AU - Yin, Frank C.P.

PY - 1995/10

Y1 - 1995/10

N2 - The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of 19F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and 125I‐albumin. Measurement of myocardial vascular volume by 19F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.

AB - The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of 19F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and 125I‐albumin. Measurement of myocardial vascular volume by 19F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.

KW - NMR

KW - blood

KW - myocardium

KW - perfluorochemical

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