Validation of DRAMMS among 12 popular methods in cross-subject cardiac MRI registration

Yangming Ou, Dong Hye Ye, Kilian M. Pohl, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations


Cross-subject image registration is the building block for many cardiac studies. In the literature, it is often handled by voxel-wise registration methods. However, studies are lacking to show which methods are more accurate and stable in this context. Aiming at answering this question, this paper evaluates 12 popular registration methods and validates a recently developed method DRAMMS [16] in the context of cross-subject cardiac registration. Our dataset consists of short-axis end-diastole cardiac MR images from 24 subjects, in which non-cardiac structures are removed. Each registration method was applied to all 552 image pairs. Registration accuracy is approximated by Jaccard overlap between deformed expert annotation of source image and the corresponding expert annotation of target image. This accuracy surrogate is further correlated with deformation aggressiveness, which is reflected by minimum, maximum and range of Jacobian determinants. Our study shows that DRAMMS [16] scores high in accuracy and well balances accuracy and aggressiveness in this dataset, followed by ANTs [13], MI-FFD [14], Demons [15], and ART [12]. Our findings in cross-subject cardiac registrations echo those findings in brain image registrations [7].

Original languageEnglish (US)
Title of host publicationBiomedical Image Registration - 5th International Workshop, WBIR 2012, Proceedings
Number of pages11
StatePublished - 2012
Externally publishedYes
Event5th International Workshop on Biomedical Image Registration, WBIR 2012 - Nashville, TN, United States
Duration: Jul 7 2012Jul 8 2012

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7359 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other5th International Workshop on Biomedical Image Registration, WBIR 2012
Country/TerritoryUnited States
CityNashville, TN


  • Cardiac MRI
  • Evaluation
  • Image Registration
  • Validation

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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