Vaginal spermicides and outcome of pregnancy: Findings in a large cohort study

George Huggins, Martin Vessey, Rosemary Flavel, David Yeates, Klim McPherson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


By the end of 1980, 5729 singleton planned pregnancies, 1552 singleton unplanned pregnancies, and 81 multiple pregnancies had been observed among the 17032 participants in the Oxford-Family Planning Association contraceptive study. The outcome of these pregnancies was investigated in relation to the use of vaginal spermicides. There was some suggestion that spermicide use might have a small adverse effect on the risk of congenital malformations, especially among infants conceived as a result of contraceptive failure. There was not, however, any evidence of any other adverse effect of spermicide use. In particular, the results provide strong evidence against the hypothesis that spermicide use has any appreciable effect on the risk of spontaneous abortion.

Original languageEnglish (US)
Pages (from-to)219-230
Number of pages12
Issue number3
StatePublished - Mar 1982
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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