Vaginal necrosis: A rare late toxicity after radiation therapy

Angela Y. Jia, Akila N. Viswanathan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Vaginal necrosis is a late radiation tissue injury with serious morbidity complications. It is rare, and its incidence is not well assessed in prospective trials. Patient comorbidities and radiation dose can significantly increase the risk. As treatment of gynecologic malignancies often involve a multidisciplinary approach, timely diagnosis and appropriate management by physicians of the team are crucial. Untreated vaginal necrosis can lead to infection, hemorrhage, necrosis-related fistulation to the bladder or rectum, perforation, and death. In this review, we describe the pathophysiology of vaginal necrosis, its clinical course, and management options.

Original languageEnglish (US)
Pages (from-to)602-609
Number of pages8
JournalGynecologic oncology
Issue number2
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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