Vaginal clear cell adenocarcinoma in the United States

Edward L. Trimble, Lawrence V. Rubinstein, Herman R. Menck, Benjamin F. Hankey, Carol Kosary, Ruthann M. Giusti

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We elected to examine available information from several sources to approximate the annual number of cases of vaginal adenocarcinoma in the United States for recent years. Data were obtained from the Registry on Hormonal Transplacental Carcinogenesis, the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute, the National Cancer Databank of the American College of Surgeons Commission on Cancer, and a survey of gynecologic oncologists practicing in the United States. In 1990 a total of 33 new cases and 11 recurrences were reported, while in 1991 23 new cases and 8 recurrences were reported. Neither SEER nor the Registry appear to provide adequate surveillance for this rare disease. Phase III clinical trials are not feasible, given the small number of patients. Statistically effective phase II one-armed studies to investigate new agents in the treatment of advanced or recurrent vaginal clear cell cancer may be possible. Effective mobilization of patients and physicians will be required for such trials to be completed in a timely manner.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalGynecologic oncology
Issue number1
StatePublished - Apr 1996
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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