TY - JOUR
T1 - VAGINAL BLEEDING DISTURBANCES ASSOCIATED bWITH THE DISCONTINUATION OF LONG‐ACTING INJECTABLE CONTRACEPTIVES
T2 - FROM THE WORLD HEALTH ORGANIZATION SPECIAL PROGRAMME FOR RESEARCH, DEVELOPMENT, AND RESEARCH TRAINING IN HUMAN REPRODUCTION; TASK FORCE ON LONG‐ACTING SYSTEMIC AGENTS FOR THE REGULATION OF FERTILITY
AU - Gray, R. H.
AU - Parker, R. A.
AU - Dlethelm, P.
PY - 1981/3
Y1 - 1981/3
N2 - A randomized comparative trial of 832 women receiving norethisterone oenanthate (NET‐OEN) and 846 women receiving depot medroxyprogesterone acetate (DMPA) injections at 12 week intervals was conducted in 10 centres. The pregnancy rate with NET‐OEN was significantly higher than with DMPA. The termination rate for amenorrhoea was substantially lower with NET‐OEN than DMPA, whereas the discontinuation rates for bleeding problems were similar with the two drugs. Analysis of bleeding patterns among continuing and discontinuing users suggests that women tolerated frequent bleeding episodes, but found prolonged bleeding or prolonged bleeding‐free intervals unacceptable. Bleeding for more than 30 days during an injection interval and complete amenorrhoea for a whole injection interval were jointly associated with 43.7 per cent of all terminations among NET‐OEN users and 64.5 per cent of all terminations among DMPA users. In future efforts to improve the acceptability of long‐acting injectable contraceptives, more attention should be given to the control of prolonged amenorrhoea and prolonged bleeding.
AB - A randomized comparative trial of 832 women receiving norethisterone oenanthate (NET‐OEN) and 846 women receiving depot medroxyprogesterone acetate (DMPA) injections at 12 week intervals was conducted in 10 centres. The pregnancy rate with NET‐OEN was significantly higher than with DMPA. The termination rate for amenorrhoea was substantially lower with NET‐OEN than DMPA, whereas the discontinuation rates for bleeding problems were similar with the two drugs. Analysis of bleeding patterns among continuing and discontinuing users suggests that women tolerated frequent bleeding episodes, but found prolonged bleeding or prolonged bleeding‐free intervals unacceptable. Bleeding for more than 30 days during an injection interval and complete amenorrhoea for a whole injection interval were jointly associated with 43.7 per cent of all terminations among NET‐OEN users and 64.5 per cent of all terminations among DMPA users. In future efforts to improve the acceptability of long‐acting injectable contraceptives, more attention should be given to the control of prolonged amenorrhoea and prolonged bleeding.
UR - http://www.scopus.com/inward/record.url?scp=0019504132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019504132&partnerID=8YFLogxK
U2 - 10.1111/j.1471-0528.1981.tb00988.x
DO - 10.1111/j.1471-0528.1981.tb00988.x
M3 - Article
C2 - 7008825
AN - SCOPUS:0019504132
SN - 1470-0328
VL - 88
SP - 317
EP - 321
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 3
ER -