Utility of measuring (1,3)-β-D-Glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection

Jennifer L. Lyons; Kiran T. Thakur; Rick Lee; Tonya Watkins; Carlos A. Pardo; Kathryn A. Carson; Barbara Markley; Malcolm A. Finkelman; Kieren A. Marr; Karen L. Roos; Sean X. Zhang

doi:10.1128/JCM.02301-14

Utility of measuring (1,3)-β-D-Glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection

Jennifer L. Lyons, Kiran T. Thakur, Rick Lee, Tonya Watkins, Carlos A. Pardo, Kathryn A. Carson, Barbara Markley, Malcolm A. Finkelman, Kieren A. Marr, Karen L. Roos, Sean X. Zhang

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31 Scopus citations

Abstract

(1-3)-β-D-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.

Original language	English (US)
Pages (from-to)	319-322
Number of pages	4
Journal	Journal of clinical microbiology
Volume	53
Issue number	1
DOIs	https://doi.org/10.1128/JCM.02301-14
State	Published - Jan 1 2015

ASJC Scopus subject areas

Microbiology (medical)

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abstract = "(1-3)-β-D-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.",

author = "Lyons, {Jennifer L.} and Thakur, {Kiran T.} and Rick Lee and Tonya Watkins and Pardo, {Carlos A.} and Carson, {Kathryn A.} and Barbara Markley and Finkelman, {Malcolm A.} and Marr, {Kieren A.} and Roos, {Karen L.} and Zhang, {Sean X.}",

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AU - Lyons, Jennifer L.

AU - Thakur, Kiran T.

AU - Lee, Rick

AU - Watkins, Tonya

AU - Pardo, Carlos A.

AU - Carson, Kathryn A.

AU - Markley, Barbara

AU - Finkelman, Malcolm A.

AU - Marr, Kieren A.

AU - Roos, Karen L.

AU - Zhang, Sean X.

PY - 2015/1/1

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N2 - (1-3)-β-D-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.

AB - (1-3)-β-D-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.

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Utility of measuring (1,3)-β-D-Glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection

Abstract

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