Using guinea pigs in studies relevant to asthma and COPD

Brendan J. Canning; Yangling Chou

doi:10.1016/j.pupt.2008.01.004

Using guinea pigs in studies relevant to asthma and COPD

Brendan J. Canning, Yangling Chou

School of Medicine

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human and guinea pig airways and the many similarities in physiological processes, especially airway autonomic control and the response to allergen. The primary disadvantages to using guinea pigs are the lack of transgenic methods, limited numbers of guinea pig strains for comparative studies and a prominent axon reflex that is unlikely to be present in human airways. These attributes and various models developed in guinea pigs are discussed.

Original language	English (US)
Pages (from-to)	702-720
Number of pages	19
Journal	Pulmonary Pharmacology and Therapeutics
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.pupt.2008.01.004
State	Published - Oct 2008

Keywords

Autonomic
IL-5
Influenza
Leukotrienes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Biochemistry, medical
Pharmacology (medical)

Access to Document

10.1016/j.pupt.2008.01.004

Cite this

@article{34bacccb82134c88b309779022d07432,

title = "Using guinea pigs in studies relevant to asthma and COPD",

abstract = "The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human and guinea pig airways and the many similarities in physiological processes, especially airway autonomic control and the response to allergen. The primary disadvantages to using guinea pigs are the lack of transgenic methods, limited numbers of guinea pig strains for comparative studies and a prominent axon reflex that is unlikely to be present in human airways. These attributes and various models developed in guinea pigs are discussed.",

keywords = "Autonomic, IL-5, Influenza, Leukotrienes",

author = "Canning, {Brendan J.} and Yangling Chou",

year = "2008",

month = oct,

doi = "10.1016/j.pupt.2008.01.004",

language = "English (US)",

volume = "21",

pages = "702--720",

journal = "Pulmonary Pharmacology and Therapeutics",

issn = "1094-5539",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Using guinea pigs in studies relevant to asthma and COPD

AU - Canning, Brendan J.

AU - Chou, Yangling

PY - 2008/10

Y1 - 2008/10

N2 - The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human and guinea pig airways and the many similarities in physiological processes, especially airway autonomic control and the response to allergen. The primary disadvantages to using guinea pigs are the lack of transgenic methods, limited numbers of guinea pig strains for comparative studies and a prominent axon reflex that is unlikely to be present in human airways. These attributes and various models developed in guinea pigs are discussed.

AB - The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human and guinea pig airways and the many similarities in physiological processes, especially airway autonomic control and the response to allergen. The primary disadvantages to using guinea pigs are the lack of transgenic methods, limited numbers of guinea pig strains for comparative studies and a prominent axon reflex that is unlikely to be present in human airways. These attributes and various models developed in guinea pigs are discussed.

KW - Autonomic

KW - IL-5

KW - Influenza

KW - Leukotrienes

UR - http://www.scopus.com/inward/record.url?scp=50849107377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50849107377&partnerID=8YFLogxK

U2 - 10.1016/j.pupt.2008.01.004

DO - 10.1016/j.pupt.2008.01.004

M3 - Article

C2 - 18462968

AN - SCOPUS:50849107377

SN - 1094-5539

VL - 21

SP - 702

EP - 720

JO - Pulmonary Pharmacology and Therapeutics

JF - Pulmonary Pharmacology and Therapeutics

IS - 5

ER -

Using guinea pigs in studies relevant to asthma and COPD

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this