Using Biomarkers for Management of Perinatal Brain Injury

Research output: Chapter in Book/Report/Conference proceedingChapter


Neonates can suffer neurologic injury of various etiologies but current therapeutic options and neurological monitoring and prognostication methods are limited. In this chapter, we review acute blood-based biomarkers that could serve as diagnostic tools to identify infants with neurologic injury, discriminate severity, monitor treatment efficacy and prognosticate recovery and any long-term disability. We discuss the potential advantages of combining biomarkers from multiple cellular pathways that may complement each other to identify distinct injury mechanisms and determine the timing of injury. Lastly, we discuss potential applications for blood-based biomarkers in neonatal encephalopathy, neonatal seizures, or other acute events such as cardiopulmonary arrest.

Original languageEnglish (US)
Title of host publicationPrinciples of Neonatology
Number of pages3
ISBN (Electronic)9780323694155
StatePublished - Jan 1 2023


  • Extracorporeal Life Support Organization registry
  • GFAP
  • S100b
  • amplitude integrated electroencephalography
  • asphyxia
  • astrocytic injury
  • astroglial cytoskeleton
  • biomarkers
  • brain derived neurotrophic factor
  • brain-specific proteins
  • cerebral palsy
  • cerebrospinal fluid
  • cytoskeletal intermediate filament protein
  • extracorporeal cardiopulmonary resuscitation
  • glial fibrillary acidic protein
  • hypoxic-ischemic encephalopathy
  • intercellular adhesion molecule-5
  • meconium
  • monocyte chemoattractant protein 1
  • neuron specific enolase
  • neuronal biomarker
  • traumatic brain injury
  • urinary biomarkers

ASJC Scopus subject areas

  • General Medicine


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