User-friendly method for rapid brain and CSF volume calculation using transaxial MRI images

Gordon J. Harris, Edward H. Rhew, Thomas Noga, Godfrey D. Pearlson

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A reliable computer method was developed for straightforward, rapid determination of whole brain and cerebrospinal fluid (CSF) volumes from a set of contiguous transaxial magnetic resonance images. The semiautomatic algorithm used a threshold-guided edge follower. Subtraction of proton-weighted from T2-weighted images was used to highlight CSF. Phantom studies were used for validity assessment. Interrater and intrarater reliability and correlation with manual measurement were excellent. Percent CSF and brain volumes were determined for small groups of Alzheimer's disease, HIV seropositive, obsessive-compulsive disorder, and schizophrenic patients as well as for young and elderly normal controls.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalPsychiatry Research: Neuroimaging
Issue number1
StatePublished - May 1991
Externally publishedYes


  • Brain volume
  • cerebrospinal fluid percentage
  • computer methods
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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