Use of saliva lithium determinations for monitoring lithium therapy

S. H. Preskorn, D. R. Abernethy, W. V. McKnelly

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


During acute and chronic administrations of lithium, 25 patients were studied to determine the effect of other psychotropic drugs on the plasma-saliva lithium concentration correlations. Changes, even discontinuation, in either tricyclic antidepressants or neuroleptics did not affect the plasma-saliva ratio which had an overall correlation coefficient of r = 0.79. The relationship using linear regression analysis was described by the equation, y = 2.27x - 0.45. Individual patients' plasma-salivary relations were described by this equation in 87% of cases. The study extends the usefulness of these determinations to include patients on lithium and neuroleptics or tricyclic antidepressants.

Original languageEnglish (US)
Pages (from-to)756-758
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number10 I
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Psychiatry and Mental health


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