TY - JOUR
T1 - Use of functional analysis methodology in the evaluation of medication effects
AU - Crosland, Kimberly A.
AU - Zarcone, Jennifer R.
AU - Lindauer, Steven E.
AU - Valdovinos, Maria G.
AU - Zarcone, Troy J.
AU - Hellings, Jessica A.
AU - Schroeder, Stephen R.
N1 - Funding Information:
This study was supported by NICHD grants HD26927, HD02528, and HD23042. The authors would like to thank Todd McKerchar, Paige Morse, Matthew Reese, and David Richman for their assistance with conducting the study. Maria Valdovinos is now at Vanderbilt University, Nashville, TN. We also wish to thank the participants, their families, and staff for their cooperation in conducting this study.
PY - 2003/6
Y1 - 2003/6
N2 - The atypical antipsychotic medication risperidone was evaluated using a double-blind, placebo-controlled design in the treatment of destructive behavior in two individuals with autism. Premedication functional analyses indicated that destructive behavior was maintained by escape from demands, attention, or access to tangible items. For both individuals, destructive behavior during the demand condition was significantly reduced during the medication phases, whereas destructive behavior continued to occur to obtain tangible items (Reggie) and attention (Sean). In addition, there appeared to be a differential effect of the medication on self-injurious behavior (SIB) versus aggression for Sean. Results of the study demonstrate how functional analysis may provide information on those conditions and behaviors that are most likely to be affected by a specific medication.
AB - The atypical antipsychotic medication risperidone was evaluated using a double-blind, placebo-controlled design in the treatment of destructive behavior in two individuals with autism. Premedication functional analyses indicated that destructive behavior was maintained by escape from demands, attention, or access to tangible items. For both individuals, destructive behavior during the demand condition was significantly reduced during the medication phases, whereas destructive behavior continued to occur to obtain tangible items (Reggie) and attention (Sean). In addition, there appeared to be a differential effect of the medication on self-injurious behavior (SIB) versus aggression for Sean. Results of the study demonstrate how functional analysis may provide information on those conditions and behaviors that are most likely to be affected by a specific medication.
KW - Aggression
KW - Autism
KW - Functional analysis
KW - Risperidone
KW - Self-injurious behavior
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U2 - 10.1023/A:1024402500425
DO - 10.1023/A:1024402500425
M3 - Article
C2 - 12908830
AN - SCOPUS:0042707915
SN - 0162-3257
VL - 33
SP - 271
EP - 279
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 3
ER -