Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue

Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, David Straton, Sharan Ramaswamy, Jessica C. Ramella-Roman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Mueller matrix polarimetry and polarization-sensitive optical coherence tomography (PS-OCT) are two emerging techniques utilized in the assessment of tissue anisotropy. While PS-OCT can provide cross-sectional images of local tissue birefringence through its polarimetric sensitivity, Mueller matrix polarimetry can be used to measure bulk polarimetric properties such as depolarization, diattenuation, and retardance. To this day true quantification of PS-OCT data can be elusive, partly due to the reliance on inverse models for the characterization of tissue birefringence and the influence of instrumentation noise. Similarly for Mueller matrix polarimetry, calculation of retardance or depolarization may be influenced by tissue heterogeneities that could be monitored with PS-OCT. Here, we propose an instrument that combines Mueller matrix polarimetry and PS-OCT. Through the co-registration of the two systems, we aim at achieving a better understanding of both modalities.

Original languageEnglish (US)
Article number071109
JournalJournal of Biomedical Optics
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • birefringence
  • collagen
  • Mueller matrix
  • polarization
  • polarization-sensitive optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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