Use of Antidepressants in Medically Ill Older Patients

Harold G. Koenig, John C.S. Breitner

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Major depression is common in older medical patients, and it can exert a deleterious effect on the treatment, course, and outcome of physical illnesses. Tricyclic or tetracyclic antidepressants (TCAs) and psychosocial interventions often play a role in the treatment of depressed medically ill patients, but well-founded doubts about the efficacy and the safety of TCAs in older, frail medical patients have developed. Based on a review of current knowledge about antidepressant use in these patients, the authors recommend the cautious use of TCAs in medically ill older patients until more data are available.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
Issue number1
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health


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