Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders

Benjamin L. Handen; Cynthia R. Johnson; Eric M. Butter; Luc Lecavalier; Lawrence Scahill; Michael G. Aman; Christopher J. McDougle; L. Eugene Arnold; Naomi B. Swiezy; Denis G. Sukhodolsky; James A. Mulick; Susan W. White; Karen Bearss; Jill A. Hollway; Kimberly A. Stigler; James Dziura; Sunkyung Yu; Kelley Sacco; Benedetto Vitiello

doi:10.1007/s10882-012-9316-y

Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders

Benjamin L. Handen, Cynthia R. Johnson, Eric M. Butter, Luc Lecavalier, Lawrence Scahill, Michael G. Aman, Christopher J. McDougle, L. Eugene Arnold, Naomi B. Swiezy, Denis G. Sukhodolsky, James A. Mulick, Susan W. White, Karen Bearss, Jill A. Hollway, Kimberly A. Stigler, James Dziura, Sunkyung Yu, Kelley Sacco, Benedetto Vitiello

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10 Scopus citations

Abstract

A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4-13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition (p =.0002) and 12 % increase in compliance to parental requests (p =.004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement (p =.001) and fewer repeated requests for compliance (p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement (p =.01) and fewer restrictive statements (p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures.

Original language	English (US)
Pages (from-to)	355-371
Number of pages	17
Journal	Journal of Developmental and Physical Disabilities
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/s10882-012-9316-y
State	Published - Jun 2013
Externally published	Yes

Keywords

Autism
Autism spectrum disorder
Behavioral interventions
Clinical trials
Observational measures
Parent training

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Developmental and Educational Psychology

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10.1007/s10882-012-9316-y

Cite this

Handen, B. L., Johnson, C. R., Butter, E. M., Lecavalier, L., Scahill, L., Aman, M. G., McDougle, C. J., Arnold, L. E., Swiezy, N. B., Sukhodolsky, D. G., Mulick, J. A., White, S. W., Bearss, K., Hollway, J. A., Stigler, K. A., Dziura, J., Yu, S., Sacco, K., & Vitiello, B. (2013). Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders. Journal of Developmental and Physical Disabilities, 25(3), 355-371. https://doi.org/10.1007/s10882-012-9316-y

Handen, BL, Johnson, CR, Butter, EM, Lecavalier, L, Scahill, L, Aman, MG, McDougle, CJ, Arnold, LE, Swiezy, NB, Sukhodolsky, DG, Mulick, JA, White, SW, Bearss, K, Hollway, JA, Stigler, KA, Dziura, J, Yu, S, Sacco, K & Vitiello, B 2013, 'Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders', Journal of Developmental and Physical Disabilities, vol. 25, no. 3, pp. 355-371. https://doi.org/10.1007/s10882-012-9316-y

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title = "Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders",

abstract = "A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4-13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition (p =.0002) and 12 % increase in compliance to parental requests (p =.004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement (p =.001) and fewer repeated requests for compliance (p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement (p =.01) and fewer restrictive statements (p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures.",

keywords = "Autism, Autism spectrum disorder, Behavioral interventions, Clinical trials, Observational measures, Parent training",

author = "Handen, {Benjamin L.} and Johnson, {Cynthia R.} and Butter, {Eric M.} and Luc Lecavalier and Lawrence Scahill and Aman, {Michael G.} and McDougle, {Christopher J.} and Arnold, {L. Eugene} and Swiezy, {Naomi B.} and Sukhodolsky, {Denis G.} and Mulick, {James A.} and White, {Susan W.} and Karen Bearss and Hollway, {Jill A.} and Stigler, {Kimberly A.} and James Dziura and Sunkyung Yu and Kelley Sacco and Benedetto Vitiello",

note = "Funding Information: Acknowledgement of funding Supported by the following cooperative agreement grants from the National Institute of Mental Health (NIMH): U10MH66768 (P.I.: M. Aman), U10MH66766 (P.I.: C. McDougle), and U10MH66764 (P.I.: L. Scahill).",

year = "2013",

month = jun,

doi = "10.1007/s10882-012-9316-y",

language = "English (US)",

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T1 - Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders

AU - Handen, Benjamin L.

AU - Johnson, Cynthia R.

AU - Butter, Eric M.

AU - Lecavalier, Luc

AU - Scahill, Lawrence

AU - Aman, Michael G.

AU - McDougle, Christopher J.

AU - Arnold, L. Eugene

AU - Swiezy, Naomi B.

AU - Sukhodolsky, Denis G.

AU - Mulick, James A.

AU - White, Susan W.

AU - Bearss, Karen

AU - Hollway, Jill A.

AU - Stigler, Kimberly A.

AU - Dziura, James

AU - Yu, Sunkyung

AU - Sacco, Kelley

AU - Vitiello, Benedetto

N1 - Funding Information: Acknowledgement of funding Supported by the following cooperative agreement grants from the National Institute of Mental Health (NIMH): U10MH66768 (P.I.: M. Aman), U10MH66766 (P.I.: C. McDougle), and U10MH66764 (P.I.: L. Scahill).

PY - 2013/6

Y1 - 2013/6

N2 - A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4-13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition (p =.0002) and 12 % increase in compliance to parental requests (p =.004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement (p =.001) and fewer repeated requests for compliance (p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement (p =.01) and fewer restrictive statements (p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures.

AB - A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4-13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition (p =.0002) and 12 % increase in compliance to parental requests (p =.004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement (p =.001) and fewer repeated requests for compliance (p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement (p =.01) and fewer restrictive statements (p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures.

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KW - Autism spectrum disorder

KW - Behavioral interventions

KW - Clinical trials

KW - Observational measures

KW - Parent training

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JO - Journal of Developmental and Physical Disabilities

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ER -

Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders

Abstract

Keywords

ASJC Scopus subject areas

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