US EPA particulate matter research centers: Summary of research results for 2005-2011

Patrick N. Breysse, Ralph J. Delfino, Francesca Dominici, Alison C.P. Elder, Mark W. Frampton, John R. Froines, Alison S. Geyh, John J. Godleski, Diane R. Gold, Philip K. Hopke, Petros Koutrakis, Ning Li, Günter Oberdörster, Kent E. Pinkerton, Jonathan M. Samet, Mark J. Utell, Anthony S. Wexler

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The US Environmental Protection Agency funded five academic research centers in 2005 to address uncertainties in the health effects caused by airborne particulate matter (PM) as suggested by the 1998 National Research Council report, "Research Priorities for Airborne Particulate Matter." The centers employed multidisciplinary teams of epidemiologists, toxicologists, atmospheric scientists, engineers, and chemists to approach four key research themes: susceptibility to PM, biological mechanisms of PM response, exposure-response relationships, and source linkages. This review presents selected accomplishments in these categories from the past 5-year period. Publications from the centers are summarized to provide both an overview of the accomplishments to date and easy reference to much of the original literature published by the centers. Numerous investigators worked together within and across centers to investigate the relationships between atmospheric PM and health effects, including (a) the role of reactive oxygen species, inflammation, the nervous system, and the cardiovascular system, (b) particle characteristics such as size, composition, source, and temporal pattern of exposure, and (c) phenotypic and genotypic characteristics of the population that influence the level of exposure and risk in response to a given exposure.

Original languageEnglish (US)
Pages (from-to)333-355
Number of pages23
JournalAir Quality, Atmosphere and Health
Issue number2
StatePublished - Jun 2013


  • Acute effects
  • Air pollution
  • Biological mechanisms
  • Chronic effects
  • Epidemiological associations
  • Exposure
  • Particulate matter
  • Source-health relationships
  • Susceptibility

ASJC Scopus subject areas

  • Pollution
  • Atmospheric Science
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis


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