TY - JOUR
T1 - Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain
T2 - The Hortega Study
AU - Domingo-Relloso, Arce
AU - Grau-Perez, Maria
AU - Galan-Chilet, Inmaculada
AU - Garrido-Martinez, Maria J.
AU - Tormos, Carmen
AU - Navas-Acien, Ana
AU - Gomez-Ariza, Jose L.
AU - Monzo-Beltran, Lidia
AU - Saez-Tormo, Guillermo
AU - Garcia-Barrera, Tamara
AU - Dueñas Laita, Antonio
AU - Briongos Figuero, Laisa S.
AU - Martin-Escudero, Juan C.
AU - Chaves, F. Javier
AU - Redon, Josep
AU - Tellez-Plaza, Maria
N1 - Funding Information:
This work was supported by the Strategic Action for Research in Health Sciences [ CP12/03080 , PI10/0082 , PI13/01848 , PI07/0497 and PI11/00726 ]; GRUPOS 03/101 , PROMETEO/2009/029 and 2005/027 , AMP07/075 and ACOMP/2013/039 from the Valencia Government ; GRS/279/A/08 from Castilla-Leon Government ; European Network of Excellence Ingenious Hypercare ( EPSS-037093 ) from the European Commission ; Retics ( PREDIMED RD06/0045/0006 ); CIBER Fisiopatología Obesidad y Nutrición (CIBERobn) [ CIBER-02-08-2009 , CB06/03 and CB12/03/30016 ] and CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM CB07/0/018 ). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER). The authors declare they have no actual or potential competing financial interests.
Publisher Copyright:
© 2018 The Authors
PY - 2019/2
Y1 - 2019/2
N2 - Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03–1.27) for Mo, 1.17 (1.05–1.31) for Ba, 1.23 (1.04–1.46) for Cr and 1.18 (1.00–1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03–1.24) for Zn and 1.12 (1.02–1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01–1.23) for Zn and 1.09 (0.99–1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
AB - Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03–1.27) for Mo, 1.17 (1.05–1.31) for Ba, 1.23 (1.04–1.46) for Cr and 1.18 (1.00–1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03–1.24) for Zn and 1.12 (1.02–1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01–1.23) for Zn and 1.09 (0.99–1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
KW - Metal mixtures
KW - Oxidative stress
KW - Population-based
KW - Urine metals
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U2 - 10.1016/j.envint.2018.11.055
DO - 10.1016/j.envint.2018.11.055
M3 - Article
C2 - 30529889
AN - SCOPUS:85057843556
SN - 0160-4120
VL - 123
SP - 171
EP - 180
JO - Environment international
JF - Environment international
ER -