Abstract
Antigen-antibody interaction and fibrin deposition at the glomerular basement membrane can release activators that ultimately convert fibrin into degradation products of varying molecular size. Thus, increased urinary fibrinogen/fibrin split products (FSP) might be expected in active lupus nephritis. A longitudinal study was done on 27 patients with biopsy-proven lupus nephritis. Those patients who were persistent FSP excretors were found to be at a significantly greater risk of progressive nephritis and renal death than those who were FSP negative. It is suggested that FSP excretion in lupus nephritis, particularly on a continued basis and despite normalization of other renal disease parameters, is a grave prognostic sign.
Original language | English (US) |
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Pages (from-to) | 43-49 |
Number of pages | 7 |
Journal | Journal of Rheumatology |
Volume | 3 |
Issue number | 1 |
State | Published - Mar 1 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology