Urinary fibrin split products in lupus nephritis.

T. M. Zizic, W. F. Cwazka, N. S. Young, M. B. Stevens

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Antigen-antibody interaction and fibrin deposition at the glomerular basement membrane can release activators that ultimately convert fibrin into degradation products of varying molecular size. Thus, increased urinary fibrinogen/fibrin split products (FSP) might be expected in active lupus nephritis. A longitudinal study was done on 27 patients with biopsy-proven lupus nephritis. Those patients who were persistent FSP excretors were found to be at a significantly greater risk of progressive nephritis and renal death than those who were FSP negative. It is suggested that FSP excretion in lupus nephritis, particularly on a continued basis and despite normalization of other renal disease parameters, is a grave prognostic sign.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalJournal of Rheumatology
Issue number1
StatePublished - Mar 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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