Uric acid and inflammatory markers

Carmelinda Ruggiero, Antonio Cherubini, Alessandro Ble, Angelo J G Bos, Marcello Maggio, Vishwa D. Dixit, Fulvio Lauretani, Stefania Bandinelli, Umberto Senin, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

360 Scopus citations


Aims: The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. Methods and results: We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of persons aged 65-95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α) were measured. Complete information on potential confounders was collected using standard methods. WBC (P = 0.0001), neutrophils (P <0.0001), C-reactive protein (P <0.0001), IL-1ra (P <0.0001), IL-6 (P = 0.0004), sIL-6r (P = 0.002), IL-18 (P <0.0001), TNF-α (P = 0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P = 0.004) and IL-6 (P =

Original languageEnglish (US)
Pages (from-to)1174-1181
Number of pages8
JournalEuropean Heart Journal
Issue number10
StatePublished - May 2006
Externally publishedYes


  • Comorbidity
  • Elderly
  • Inflammation
  • Metabolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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