Uremic lung: New insights into a forgotten condition

Paul J. Scheel, Manchang Liu, Hamid Rabb

Research output: Contribution to journalComment/debatepeer-review

72 Scopus citations


The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.

Original languageEnglish (US)
Pages (from-to)849-851
Number of pages3
JournalKidney international
Issue number7
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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