Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha

M. De Bruin; K. Smid; M. A. Van Der Ent; M. Fukushima; H. M. Pinedo; G. J. Peters

doi:10.1081/NCN-200027622

Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha

M. De Bruin, K. Smid, M. A. Van Der Ent, M. Fukushima, H. M. Pinedo, G. J. Peters

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.

Original language	English (US)
Pages (from-to)	1367-1370
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	23
Issue number	8-9
DOIs	https://doi.org/10.1081/NCN-200027622
State	Published - 2004
Externally published	Yes

Keywords

Interferon-gamma
Platelet derived endothelial cell growth factor
Thymidine phosphorylase

ASJC Scopus subject areas

Genetics
Biochemistry

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10.1081/NCN-200027622

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title = "Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha",

abstract = "Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.",

keywords = "Interferon-gamma, Platelet derived endothelial cell growth factor, Thymidine phosphorylase",

author = "{De Bruin}, M. and K. Smid and {Van Der Ent}, {M. A.} and M. Fukushima and Pinedo, {H. M.} and Peters, {G. J.}",

year = "2004",

doi = "10.1081/NCN-200027622",

language = "English (US)",

volume = "23",

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T1 - Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha

AU - De Bruin, M.

AU - Smid, K.

AU - Van Der Ent, M. A.

AU - Fukushima, M.

AU - Pinedo, H. M.

AU - Peters, G. J.

PY - 2004

Y1 - 2004

N2 - Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.

AB - Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.

KW - Interferon-gamma

KW - Platelet derived endothelial cell growth factor

KW - Thymidine phosphorylase

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SN - 1525-7770

VL - 23

SP - 1367

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JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 8-9

ER -

Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha

Abstract

Keywords

ASJC Scopus subject areas

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