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Keyphrases
Growth Factors
100%
Breast Cancer Cells
100%
Estrogen Receptor 1 (ESR1)
100%
Insulin Receptor Substrate 1 (IRS1)
100%
Y537S
100%
D538G
100%
Mutant Cells
50%
Mutant Cell Line
20%
Endocrine Resistance
20%
Estrogen Receptor
10%
Breast Tumor
10%
Quantitative PCR
10%
Somatic mutation
10%
Small Interfering RNA (siRNA)
10%
Growth Inhibition
10%
Ligand-binding Domain
10%
Regulatory Genes
10%
Downstream Signaling
10%
Immunoblotting
10%
RNA Sequencing (RNA-seq)
10%
Combination Treatment
10%
MCF-7 Cells
10%
Study Support
10%
Multiple Genes
10%
Breast Cancer Progression
10%
Breast Tumorigenesis
10%
Cell Line Models
10%
Insulin-like Growth Factor 1 Receptor (IGF1R)
10%
High Insulin
10%
Detailed Mechanism
10%
Major Pathway
10%
Effective Concentration
10%
Breast Development
10%
Fulvestrant
10%
T47D Cells
10%
Endocrine-resistant Breast Cancer
10%
Growth Stimulation
10%
ESR1 mutation
10%
OSI-906
10%
1 Receptor
10%
Co-targeting
10%
Phosphoinositide 3-kinase/Akt
10%
Genome-edited
10%
Biochemistry, Genetics and Molecular Biology
Growth Factor
100%
Cancer Cell
100%
Upregulation
100%
Insulin Receptor
100%
Fibrinogen
100%
Cell Mutant
70%
Estrogen Receptor
10%
Somatic Mutation
10%
Carcinogenesis
10%
Phosphoinositide 3-Kinase
10%
Growth Inhibition
10%
Mediator
10%
Ligand Binding Domain
10%
Quantitative Reverse Transcription Polymerase Chain Reaction
10%
Insulin-Like Growth Factor 1
10%
Protein Kinase B
10%
RNA Sequence
10%
Effective Concentration
10%
Growth Stimulation
10%
Breast Development
10%
Immunoblotting
10%
Small Interfering RNA
10%
Fulvestrant
10%