Upgrading the BCL-2 Network

Heidi L. Galonek; J. Marie Hardwick

doi:10.1038/ncb1206-1317

Upgrading the BCL-2 Network

Heidi L. Galonek
, J. Marie Hardwick

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

Original language	English (US)
Pages (from-to)	1317-1319
Number of pages	3
Journal	Nature cell biology
Volume	8
Issue number	12
DOIs	https://doi.org/10.1038/ncb1206-1317
State	Published - Dec 2006

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb1206-1317

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abstract = "The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.",

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AB - The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

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Upgrading the BCL-2 Network

Abstract

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