Upgrading the BCL-2 Network

Heidi L. Galonek, J. Marie Hardwick

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

Original languageEnglish (US)
Pages (from-to)1317-1319
Number of pages3
JournalNature cell biology
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Cell Biology


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