Update on role of chemotherapy in head and neck squamous cell cancer

S. Marur; A. A. Forastiere

doi:10.1007/s13193-010-0021-y

Update on role of chemotherapy in head and neck squamous cell cancer

S. Marur, A. A. Forastiere

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Head and neck squamous cell cancer (HNSCC) is most commonly a tobacco-related disease, affecting nearly 600,000 people worldwide each year. For decades, HNSCC has been treated successfully with multimodality treatments including, surgery, radiation, and chemotherapy, though the 'perfect' treatment paradigm remains elusive. This review will discuss a number of clinical trials, comparing various combinations of chemotherapy and the settings in which they are most successful. Promising research and recent data on the combination of cytotoxic chemotherapy with new biological agents indicate chemotherapy plays a critical role in treatment of HNSCC and will only continue to improve.

Original language	English (US)
Pages (from-to)	85-95
Number of pages	11
Journal	Indian Journal of Surgical Oncology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1007/s13193-010-0021-y
State	Published - Apr 2010
Externally published	Yes

Keywords

Head and neck cancer
cetuximab
chemoradiation
chemotherapy
induction chemotherapy
targeted therapy

ASJC Scopus subject areas

Surgery
Oncology

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10.1007/s13193-010-0021-y

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title = "Update on role of chemotherapy in head and neck squamous cell cancer",

abstract = "Head and neck squamous cell cancer (HNSCC) is most commonly a tobacco-related disease, affecting nearly 600,000 people worldwide each year. For decades, HNSCC has been treated successfully with multimodality treatments including, surgery, radiation, and chemotherapy, though the 'perfect' treatment paradigm remains elusive. This review will discuss a number of clinical trials, comparing various combinations of chemotherapy and the settings in which they are most successful. Promising research and recent data on the combination of cytotoxic chemotherapy with new biological agents indicate chemotherapy plays a critical role in treatment of HNSCC and will only continue to improve.",

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AU - Forastiere, A. A.

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AB - Head and neck squamous cell cancer (HNSCC) is most commonly a tobacco-related disease, affecting nearly 600,000 people worldwide each year. For decades, HNSCC has been treated successfully with multimodality treatments including, surgery, radiation, and chemotherapy, though the 'perfect' treatment paradigm remains elusive. This review will discuss a number of clinical trials, comparing various combinations of chemotherapy and the settings in which they are most successful. Promising research and recent data on the combination of cytotoxic chemotherapy with new biological agents indicate chemotherapy plays a critical role in treatment of HNSCC and will only continue to improve.

KW - Head and neck cancer

KW - cetuximab

KW - chemoradiation

KW - chemotherapy

KW - induction chemotherapy

KW - targeted therapy

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Update on role of chemotherapy in head and neck squamous cell cancer

Abstract

Keywords

ASJC Scopus subject areas

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