TY - JOUR
T1 - Update on Hereditary Renal Cancer and Imaging Implications
AU - Walker, Stephanie M.
AU - Gautam, Rabindra
AU - Turkbey, Baris
AU - Malayeri, Ashkan
AU - Choyke, Peter L.
N1 - Funding Information:
This research was made possible through the National Institutes of Health (NIH) Medical Research Scholars Program, a public-private partnership supported jointly by the NIH and contributions to the Foundation for the NIH from the Doris Duke Charitable Foundation , Genentech , the American Association for Dental Research , the Colgate-Palmolive Company , and other private donors.
Publisher Copyright:
© 2020
PY - 2020/9
Y1 - 2020/9
N2 - Up to 8% of renal cancers are thought to have a hereditary component. Several hereditary renal cancer syndromes have been identified over the last few decades. It is important for the radiologist to be aware of findings associated with hereditary renal cancer syndromes to detect tumors early, enroll patients in appropriate surveillance programs, and improve outcomes for the patient and affected family members. This review discusses from a radiologist's perspective well-known hereditary renal cancer syndromes and emerging genetic mutations associated with renal cancer that are less well characterized, focusing on imaging features and known associations.
AB - Up to 8% of renal cancers are thought to have a hereditary component. Several hereditary renal cancer syndromes have been identified over the last few decades. It is important for the radiologist to be aware of findings associated with hereditary renal cancer syndromes to detect tumors early, enroll patients in appropriate surveillance programs, and improve outcomes for the patient and affected family members. This review discusses from a radiologist's perspective well-known hereditary renal cancer syndromes and emerging genetic mutations associated with renal cancer that are less well characterized, focusing on imaging features and known associations.
KW - Hereditary leiomyomatosis and renal cell cancer
KW - Hereditary renal cancer syndrome
KW - Renal cell carcinoma
KW - Tuberous sclerosis
KW - Von Hippel-Lindau disease
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U2 - 10.1016/j.rcl.2020.04.003
DO - 10.1016/j.rcl.2020.04.003
M3 - Review article
C2 - 32792126
AN - SCOPUS:85086380243
SN - 0033-8389
VL - 58
SP - 951
EP - 963
JO - Radiologic clinics of North America
JF - Radiologic clinics of North America
IS - 5
ER -