Update on gene modifiers in cystic fibrosis

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Several genes have been demonstrated to affect disease severity in CF. Furthermore, it is likely that gene-gene and gene-environment interactions can explain a substantial portion of the variation of lung disease. Ongoing genome-wide studies are likely to identify novel genetic modifiers. Continued exploration of the role of genetic and nongenetic modifiers of CF is likely to yield new options for combating this debilitating disease.

Original languageEnglish (US)
Pages (from-to)559-566
Number of pages8
JournalCurrent opinion in pulmonary medicine
Issue number6
StatePublished - Nov 2008


  • Cystic fibrosis
  • Genome-wide
  • Interaction
  • Modifier gene

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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