Update in atherothrombotic disease

Juan F. Viles-Gonzalez, Sunil X. Anand, Carolina Valdiviezo, Urooj Zafar, Randolf Hutter, Javier Sanz, Teresa Rius, Michael Poon, Valentin Fuster, Juan J. Badimon

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Crucial advances in our understanding of the pathogenesis of atherothrombosis, defined as atherosclerosis and its thrombotic complications, have been achieved during the past two decades. The historical hypothesis of pathogenesis ("lipid accumulation") has evolved to integrate several factors contributing to the initiation and evolution of this complex disease. Endothelial dysfunction is considered to be the earliest event in atherogenesis. Inflammation and apoptosis play critical roles in its progression and onset. Tissue factor is postulated to be a central actor in determining plaque thrombogenicity. A hyperreactive state of the blood ("vulnerable blood") may be responsible for one-third of all the acute coronary syndromes. This review will discuss emerging concepts in the pathogenesis of and therapeutic approaches to atherothrombotic disease.

Original languageEnglish (US)
Pages (from-to)197-208
Number of pages12
JournalMount Sinai Journal of Medicine
Issue number3
StatePublished - May 2004


  • Acute coronary syndromes
  • Antithrombotic therapy
  • Apoptosis
  • Atherosclerosis
  • Atherothrombosis
  • Coronary artery disease
  • Endothelial dysfunction
  • Inflammation
  • Tissue factor

ASJC Scopus subject areas

  • Medicine(all)


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