Update: Acute coronary syndromes (V). Personalized antiplatelet therapy

Paul A. Gurbel; Rahil Rafeedheen; Udaya S. Tantry

doi:10.1016/j.rec.2014.01.012

Update: Acute coronary syndromes (V). Personalized antiplatelet therapy

Paul A. Gurbel, Rahil Rafeedheen, Udaya S. Tantry

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

It is well established that high on-treatment platelet reactivity to adenosine diphosphate during clopidogrel therapy is an independent risk factor for ischemic event occurrences in a postpercutaneous coronary intervention patients. However, the precise role of platelet function testing remains debated. Platelet function testing to ensure optimal platelet inhibition has been recommended by some authorities to improve outcomes in patients treated with clopidogrel. Recent prospective, randomized trials of personalized antiplatelet therapy have failed to demonstrate a benefit of platelet function testing in improving outcomes. In this review article, we discuss the mechanisms responsible for clopidogrel nonreponsiveness, recent trials of platelet function testing, and other new developments in the field of personalized antiplatelet therapy.

Original language	English (US)
Pages (from-to)	480-487
Number of pages	8
Journal	Revista española de cardiología (English ed.)
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/j.rec.2014.01.012
State	Published - Jun 1 2014

Keywords

Determinación de genotipo
Genotyping
Personalized antiplatelet therapy
Platelet function testing
Pruebas de la función plaquetaria
Thrombosis
Tratamiento antiagregante plaquetario personalizado
Trombosis

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.rec.2014.01.012

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title = "Update: Acute coronary syndromes (V). Personalized antiplatelet therapy",

abstract = "It is well established that high on-treatment platelet reactivity to adenosine diphosphate during clopidogrel therapy is an independent risk factor for ischemic event occurrences in a postpercutaneous coronary intervention patients. However, the precise role of platelet function testing remains debated. Platelet function testing to ensure optimal platelet inhibition has been recommended by some authorities to improve outcomes in patients treated with clopidogrel. Recent prospective, randomized trials of personalized antiplatelet therapy have failed to demonstrate a benefit of platelet function testing in improving outcomes. In this review article, we discuss the mechanisms responsible for clopidogrel nonreponsiveness, recent trials of platelet function testing, and other new developments in the field of personalized antiplatelet therapy. ",

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AU - Tantry, Udaya S.

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AB - It is well established that high on-treatment platelet reactivity to adenosine diphosphate during clopidogrel therapy is an independent risk factor for ischemic event occurrences in a postpercutaneous coronary intervention patients. However, the precise role of platelet function testing remains debated. Platelet function testing to ensure optimal platelet inhibition has been recommended by some authorities to improve outcomes in patients treated with clopidogrel. Recent prospective, randomized trials of personalized antiplatelet therapy have failed to demonstrate a benefit of platelet function testing in improving outcomes. In this review article, we discuss the mechanisms responsible for clopidogrel nonreponsiveness, recent trials of platelet function testing, and other new developments in the field of personalized antiplatelet therapy.

KW - Determinación de genotipo

KW - Genotyping

KW - Personalized antiplatelet therapy

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KW - Tratamiento antiagregante plaquetario personalizado

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Update: Acute coronary syndromes (V). Personalized antiplatelet therapy

Abstract

Keywords

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