Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations

Shanmugam Saravanan; Vidya Madhavan; Rami Kantor; Sathasivam Sivamalar; Selvamurthi Gomathi; Sunil S. Solomon; Nagalingeswaran Kumarasamy; Davey M. Smith; Robert T. Schooley; Suniti Solomon; Pachamuthu Balakrishnan

doi:10.1089/aid.2011.0331

Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations

Shanmugam Saravanan, Vidya Madhavan, Rami Kantor, Sathasivam Sivamalar, Selvamurthi Gomathi, Sunil S. Solomon, Nagalingeswaran Kumarasamy, Davey M. Smith, Robert T. Schooley, Suniti Solomon, Pachamuthu Balakrishnan

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a high frequency of drug resistance mutations among patients with unusual insertions or deletions at the β₃-β₄ hairpin-loop-coding region of HIV-1 subtype C reverse transcriptase, during failure of first-line antiretroviral therapy containing only reverse transcriptase inhibitors in Chennai, India.

Original language	English (US)
Pages (from-to)	1763-1765
Number of pages	3
Journal	AIDS research and human retroviruses
Volume	28
Issue number	12
DOIs	https://doi.org/10.1089/aid.2011.0331
State	Published - Dec 1 2012
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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Saravanan, S., Madhavan, V., Kantor, R., Sivamalar, S., Gomathi, S., Solomon, S. S., Kumarasamy, N., Smith, D. M., Schooley, R. T., Solomon, S., & Balakrishnan, P. (2012). Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations. AIDS research and human retroviruses, 28(12), 1763-1765. https://doi.org/10.1089/aid.2011.0331

Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations. / Saravanan, Shanmugam; Madhavan, Vidya; Kantor, Rami et al.
In: AIDS research and human retroviruses, Vol. 28, No. 12, 01.12.2012, p. 1763-1765.

Research output: Contribution to journal › Article › peer-review

Saravanan, S, Madhavan, V, Kantor, R, Sivamalar, S, Gomathi, S, Solomon, SS, Kumarasamy, N, Smith, DM, Schooley, RT, Solomon, S & Balakrishnan, P 2012, 'Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations', AIDS research and human retroviruses, vol. 28, no. 12, pp. 1763-1765. https://doi.org/10.1089/aid.2011.0331

Saravanan S, Madhavan V, Kantor R, Sivamalar S, Gomathi S, Solomon SS et al. Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations. AIDS research and human retroviruses. 2012 Dec 1;28(12):1763-1765. doi: 10.1089/aid.2011.0331

Saravanan, Shanmugam ; Madhavan, Vidya ; Kantor, Rami et al. / Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients : Association with other resistance mutations. In: AIDS research and human retroviruses. 2012 ; Vol. 28, No. 12. pp. 1763-1765.

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AU - Schooley, Robert T.

AU - Solomon, Suniti

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Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing south Indian patients: Association with other resistance mutations

Abstract

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