Unusual demyelinating disease: A form of diffuse-disseminated sclerosis

Junichi Tanaka, Julio H. Garcia, Ramesh Khurana, Y. Kamijyo, J. E. Viloria

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A young man, in good health until the age of 22, developed progressive personality changes, lethargy, motor difficulties, urinary bladder dysfunction, and convulsions. Spinal fluid abnormalities included monocytic pleocytosis and selective increase of gamma globulins. The clinical features and the structural lesions in the central nervous system are reminiscent of disseminated-diffuse sclerosis. Oligodendrocytes appeared normal in number and showed nonspecific abnormalities. Comparison of the structural lesions found in this case with those described in several reports of demyelination indicates that the separation of this syndrome, as a distinct entity, may not be justified. We suggest that such cases be classified as myelinoclastic disorders, in the same category with multiple sclerosis and its variants.

Original languageEnglish (US)
Pages (from-to)588-593
Number of pages6
Issue number6
StatePublished - Jun 1975
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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