Untangling the complex web of IL-4-and IL-13-mediated signaling pathways

Marsha Wills-Karp, Fred D. Finkelman

Research output: Contribution to journalReview articlepeer-review

176 Scopus citations


Unraveling the exact signaling events mediating the distinct functions of the T cell-derived cytokines interleukin-4 (IL-4) and IL-13 has been challenging because they are structurally similar and share a functional signaling receptor chain. A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate-2 (IRS-2) signaling cascade through binding to its receptor. A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects.

Original languageEnglish (US)
Pages (from-to)pe55
JournalScience signaling
Issue number51
StatePublished - Dec 23 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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