Unresolved questions from the analysis of mice lacking MCU expression

Elizabeth Murphy; Xin Pan; Tiffany Nguyen; Jie Liu; Kira M. Holmström; Toren Finkel

doi:10.1016/j.bbrc.2014.04.144

Unresolved questions from the analysis of mice lacking MCU expression

Elizabeth Murphy, Xin Pan, Tiffany Nguyen, Jie Liu, Kira M. Holmström, Toren Finkel

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66 Scopus citations

Abstract

Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results.

Original language	English (US)
Pages (from-to)	384-385
Number of pages	2
Journal	Biochemical and Biophysical Research Communications
Volume	449
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2014.04.144
State	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Molecular Biology

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10.1016/j.bbrc.2014.04.144

Cite this

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abstract = "Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results.",

author = "Elizabeth Murphy and Xin Pan and Tiffany Nguyen and Jie Liu and Holmstr{\"o}m, {Kira M.} and Toren Finkel",

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AU - Nguyen, Tiffany

AU - Liu, Jie

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AU - Finkel, Toren

PY - 2014

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Unresolved questions from the analysis of mice lacking MCU expression

Abstract

ASJC Scopus subject areas

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