Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes

Fresia Pareja; Rohit Bhargava; Virginia F. Borges; Edi Brogi; Rita Canas Marques; Fatima Cardoso; Christine Desmedt; Malini Harigopal; Sunil R. Lakhani; Adrian Lee; Jose Pablo Leone; Hannah Linden; Christopher J. Lord; Caterina Marchio; Sofia D. Merajver; Emad Rakha; Jorge S. Reis-Filho; Andrea Richardson; Elinor Sawyer; Pepper Schedin; Christopher J. Schwartz; Andrew Tutt; Naoto T. Ueno; Anne Vincent-Salomon; Britta Weigelt; Y. Hannah Wen; Stuart J. Schnitt; Steffi Oesterreich

doi:10.1038/s41523-025-00719-w

Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes

Fresia Pareja
, Rohit Bhargava
, Virginia F. Borges
, Edi Brogi
, Rita Canas Marques
, Fatima Cardoso
, Christine Desmedt
, Malini Harigopal
, Sunil R. Lakhani
, Adrian Lee
, Jose Pablo Leone
, Hannah Linden
, Christopher J. Lord
, Caterina Marchio
, Sofia D. Merajver
, Emad Rakha
, Jorge S. Reis-Filho
, Andrea Richardson
, Elinor Sawyer
, Pepper Schedin

Christopher J. Schwartz, Andrew Tutt, Naoto T. Ueno, Anne Vincent-Salomon, Britta Weigelt, Y. Hannah Wen, Stuart J. Schnitt, Steffi Oesterreich

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.

Original language	English (US)
Article number	6
Journal	npj Breast Cancer
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41523-025-00719-w
State	Published - Dec 2025

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

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10.1038/s41523-025-00719-w

Cite this

Pareja, F., Bhargava, R., Borges, V. F., Brogi, E., Canas Marques, R., Cardoso, F., Desmedt, C., Harigopal, M., Lakhani, S. R., Lee, A., Leone, J. P., Linden, H., Lord, C. J., Marchio, C., Merajver, S. D., Rakha, E., Reis-Filho, J. S., Richardson, A., Sawyer, E., ... Oesterreich, S. (2025). Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes. npj Breast Cancer, 11(1), Article 6. https://doi.org/10.1038/s41523-025-00719-w

Pareja, F, Bhargava, R, Borges, VF, Brogi, E, Canas Marques, R, Cardoso, F, Desmedt, C, Harigopal, M, Lakhani, SR, Lee, A, Leone, JP, Linden, H, Lord, CJ, Marchio, C, Merajver, SD, Rakha, E, Reis-Filho, JS, Richardson, A, Sawyer, E, Schedin, P, Schwartz, CJ, Tutt, A, Ueno, NT, Vincent-Salomon, A, Weigelt, B, Wen, YH, Schnitt, SJ & Oesterreich, S 2025, 'Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes', npj Breast Cancer, vol. 11, no. 1, 6. https://doi.org/10.1038/s41523-025-00719-w

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title = "Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes",

abstract = "Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.",

author = "Fresia Pareja and Rohit Bhargava and Borges, \{Virginia F.\} and Edi Brogi and \{Canas Marques\}, Rita and Fatima Cardoso and Christine Desmedt and Malini Harigopal and Lakhani, \{Sunil R.\} and Adrian Lee and Leone, \{Jose Pablo\} and Hannah Linden and Lord, \{Christopher J.\} and Caterina Marchio and Merajver, \{Sofia D.\} and Emad Rakha and Reis-Filho, \{Jorge S.\} and Andrea Richardson and Elinor Sawyer and Pepper Schedin and Schwartz, \{Christopher J.\} and Andrew Tutt and Ueno, \{Naoto T.\} and Anne Vincent-Salomon and Britta Weigelt and Wen, \{Y. Hannah\} and Schnitt, \{Stuart J.\} and Steffi Oesterreich",

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doi = "10.1038/s41523-025-00719-w",

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AU - Pareja, Fresia

AU - Bhargava, Rohit

AU - Borges, Virginia F.

AU - Brogi, Edi

AU - Canas Marques, Rita

AU - Cardoso, Fatima

AU - Desmedt, Christine

AU - Harigopal, Malini

AU - Lakhani, Sunil R.

AU - Lee, Adrian

AU - Leone, Jose Pablo

AU - Linden, Hannah

AU - Lord, Christopher J.

AU - Marchio, Caterina

AU - Merajver, Sofia D.

AU - Rakha, Emad

AU - Reis-Filho, Jorge S.

AU - Richardson, Andrea

AU - Sawyer, Elinor

AU - Schedin, Pepper

AU - Schwartz, Christopher J.

AU - Tutt, Andrew

AU - Ueno, Naoto T.

AU - Vincent-Salomon, Anne

AU - Weigelt, Britta

AU - Wen, Y. Hannah

AU - Schnitt, Stuart J.

AU - Oesterreich, Steffi

PY - 2025/12

Y1 - 2025/12

N2 - Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.

AB - Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.

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UR - https://www.scopus.com/pages/publications/85218178998#tab=citedBy

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DO - 10.1038/s41523-025-00719-w

M3 - Review article

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VL - 11

JO - npj Breast Cancer

JF - npj Breast Cancer

IS - 1

M1 - 6

ER -

Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes

Abstract

ASJC Scopus subject areas

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