TY - JOUR
T1 - Unmasking of human lymphoid cell heteroantigens by neuraminidase treatment1
AU - Rosenberg, Steven A.
AU - Plocinik, Barbara A.
AU - Rogentine, G. Nicholas
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1972/5
Y1 - 1972/5
N2 - Treatment of human lymphoid tissue-culture cells and fresh human lymphocytes withVibrio choleraeneuraminidase (NASE) underconditions that removed 65% of the cell-surface sialic acid uncoveredsurface structures capable of reacting with substances, probably antibodies, in normal rabbit serum. Three to five times more of these surface componentswere detectable on NASE-treated cultured lymphoid cells than on untreated cells. The antibody in normal rabbit serum could be removed byabsorption with NASE-treated lymphoid cells in the presence of ethylene-diamine tetraethylacetate without lowering complement levels.—J NatCancer Inst 48: 1271-1276, 1972.
AB - Treatment of human lymphoid tissue-culture cells and fresh human lymphocytes withVibrio choleraeneuraminidase (NASE) underconditions that removed 65% of the cell-surface sialic acid uncoveredsurface structures capable of reacting with substances, probably antibodies, in normal rabbit serum. Three to five times more of these surface componentswere detectable on NASE-treated cultured lymphoid cells than on untreated cells. The antibody in normal rabbit serum could be removed byabsorption with NASE-treated lymphoid cells in the presence of ethylene-diamine tetraethylacetate without lowering complement levels.—J NatCancer Inst 48: 1271-1276, 1972.
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U2 - 10.1093/jnci/48.5.1271
DO - 10.1093/jnci/48.5.1271
M3 - Article
C2 - 4624148
AN - SCOPUS:0015337253
SN - 0027-8874
VL - 48
SP - 1271
EP - 1276
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 5
ER -