Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia

Anne Louise Oaklander; Allan J. Belzberg

doi:10.1016/S0169-328X(97)00239-8

Unilateral nerve injury down-regulates mRNA for Na⁺ channel SCN10A bilaterally in rat dorsal root ganglia

Anne Louise Oaklander, Allan J. Belzberg

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.

Original language	English (US)
Pages (from-to)	162-165
Number of pages	4
Journal	Molecular Brain Research
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/S0169-328X(97)00239-8
State	Published - Dec 1 1997

Keywords

Dorsal root ganglion
Hyperalgesia
Nerve injury
Neuropathic pain
RT-PCR
SCN10A
Voltage-gated sodium channel
α-SNS

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Access to Document

10.1016/S0169-328X(97)00239-8

Cite this

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title = "Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia",

abstract = "Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.",

keywords = "Dorsal root ganglion, Hyperalgesia, Nerve injury, Neuropathic pain, RT-PCR, SCN10A, Voltage-gated sodium channel, α-SNS",

author = "Oaklander, {Anne Louise} and Belzberg, {Allan J.}",

note = "Funding Information: We thank R. Meyer and S. Mittman for helpful suggestions and gratefully acknowledge the contributions of K. Romans. Supported in part by the Jacob and Hilda Blaustein Foundation Inc. and the Promega Corporation. ",

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AB - Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.

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KW - α-SNS

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