Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

S. R. Cox; Akshay Gupte; B. Thomas; S. Gaikwad; Vidya Mave; C. Padmapriyadarsini; T. R. Sahasrabudhe; D. Kadam; Nikhil Gupte; L. E. Hanna; A. Kagal; M. Paradkar; K. Thiruvengadam; D. Jain; S. Atre; K. Sekar; S. Raskar; S. V.B.Y. Shivakumar; R. Santhappan; S. Deshmukh; N. Pradhan; V. Kulkarni; A. Kakrani; M. S. Barthwal; T. Sawant; Andrea Deluca; Nishi Suryavanshi; Geetanjali Chander; R. Bollinger; J. E. Golub; A. Gupta

doi:10.5588/IJTLD.20.0778

Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

S. R. Cox, Akshay Gupte, B. Thomas, S. Gaikwad, Vidya Mave, C. Padmapriyadarsini, T. R. Sahasrabudhe, D. Kadam, Nikhil Gupte, L. E. Hanna, A. Kagal, M. Paradkar, K. Thiruvengadam, D. Jain, S. Atre, K. Sekar, S. Raskar, S. V.B.Y. Shivakumar, R. Santhappan, S. DeshmukhN. Pradhan, V. Kulkarni, A. Kakrani, M. S. Barthwal, T. Sawant, Andrea Deluca, Nishi Suryavanshi, Geetanjali Chander, R. Bollinger, J. E. Golub, A. Gupta

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Approximately 10% of incident TB cases worldwide are attributable to alcohol. However, evidence associating alcohol with unfavorable TB treatment outcomes is weak. METHODS: We prospectively evaluated men (>18 years) with pulmonary TB in India for up to 24 months to investigate the association between alcohol use and treatment outcomes. Unhealthy alcohol use was defined as a score of >4 on the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) scale at entry. Unfavorable TB treatment outcomes included failure, recurrence, and all-cause mortality, analyzed as composite and independent endpoints. R E S U LT S: Among 751 men, we identified unhealthy alcohol use in 302 (40%). Median age was 39 years (IQR 28-50); 415 (55%) were underweight (defined as a body mass index [BMI],18.5 kg/m²); and 198 (26%) experienced an unfavorable outcome. Unhealthy alcohol use was an independent risk factor for the composite unfavorable outcome (adjusted incidence rate ratio [aIRR] 1.47, 95% CI 1.05-2.06; P¼0.03) and death (aIRR 1.90, 95% CI 1.08-3.34; P¼ 0.03), specifically. We found significant interaction between AUDIT-C and BMI; underweight men with unhealthy alcohol use had increased risk of unfavorable outcomes (aIRR 2.22, 95% CI 1.44-3.44; P, 0.001) compared to men with BMI >18.5 kg/m² and AUDIT-C,4. CONCLUSION: Unhealthy alcohol use was independently associated with unfavorable TB treatment outcomes, highlighting the need for integrating effective alcohol interventions into TB care.

Original language	English (US)
Pages (from-to)	182-190
Number of pages	9
Journal	International Journal of Tuberculosis and Lung Disease
Volume	25
Issue number	3
DOIs	https://doi.org/10.5588/IJTLD.20.0778
State	Published - Mar 1 2021

Keywords

AUDIT
Adverse outcomes
Failure
Mortality
Recurrence

ASJC Scopus subject areas

General Medicine

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10.5588/IJTLD.20.0778

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Cox, S. R., Gupte, A., Thomas, B., Gaikwad, S., Mave, V., Padmapriyadarsini, C., Sahasrabudhe, T. R., Kadam, D., Gupte, N., Hanna, L. E., Kagal, A., Paradkar, M., Thiruvengadam, K., Jain, D., Atre, S., Sekar, K., Raskar, S., Shivakumar, S. V. B. Y., Santhappan, R., ... Gupta, A. (2021). Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men. International Journal of Tuberculosis and Lung Disease, 25(3), 182-190. https://doi.org/10.5588/IJTLD.20.0778

Cox, SR, Gupte, A, Thomas, B, Gaikwad, S, Mave, V, Padmapriyadarsini, C, Sahasrabudhe, TR, Kadam, D, Gupte, N, Hanna, LE, Kagal, A, Paradkar, M, Thiruvengadam, K, Jain, D, Atre, S, Sekar, K, Raskar, S, Shivakumar, SVBY, Santhappan, R, Deshmukh, S, Pradhan, N, Kulkarni, V, Kakrani, A, Barthwal, MS, Sawant, T, Deluca, A, Suryavanshi, N, Chander, G, Bollinger, R , Golub, JE & Gupta, A 2021, 'Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men', International Journal of Tuberculosis and Lung Disease, vol. 25, no. 3, pp. 182-190. https://doi.org/10.5588/IJTLD.20.0778

@article{eca17adcb51b4d9ab9b8dba69eb11264,

title = "Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men",

abstract = "BACKGROUND: Approximately 10% of incident TB cases worldwide are attributable to alcohol. However, evidence associating alcohol with unfavorable TB treatment outcomes is weak. METHODS: We prospectively evaluated men (>18 years) with pulmonary TB in India for up to 24 months to investigate the association between alcohol use and treatment outcomes. Unhealthy alcohol use was defined as a score of >4 on the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) scale at entry. Unfavorable TB treatment outcomes included failure, recurrence, and all-cause mortality, analyzed as composite and independent endpoints. R E S U LT S: Among 751 men, we identified unhealthy alcohol use in 302 (40%). Median age was 39 years (IQR 28-50); 415 (55%) were underweight (defined as a body mass index [BMI],18.5 kg/m2); and 198 (26%) experienced an unfavorable outcome. Unhealthy alcohol use was an independent risk factor for the composite unfavorable outcome (adjusted incidence rate ratio [aIRR] 1.47, 95% CI 1.05-2.06; P¼0.03) and death (aIRR 1.90, 95% CI 1.08-3.34; P¼ 0.03), specifically. We found significant interaction between AUDIT-C and BMI; underweight men with unhealthy alcohol use had increased risk of unfavorable outcomes (aIRR 2.22, 95% CI 1.44-3.44; P, 0.001) compared to men with BMI >18.5 kg/m2 and AUDIT-C,4. CONCLUSION: Unhealthy alcohol use was independently associated with unfavorable TB treatment outcomes, highlighting the need for integrating effective alcohol interventions into TB care.",

keywords = "AUDIT, Adverse outcomes, Failure, Mortality, Recurrence",

author = "Cox, {S. R.} and Akshay Gupte and B. Thomas and S. Gaikwad and Vidya Mave and C. Padmapriyadarsini and Sahasrabudhe, {T. R.} and D. Kadam and Nikhil Gupte and Hanna, {L. E.} and A. Kagal and M. Paradkar and K. Thiruvengadam and D. Jain and S. Atre and K. Sekar and S. Raskar and Shivakumar, {S. V.B.Y.} and R. Santhappan and S. Deshmukh and N. Pradhan and V. Kulkarni and A. Kakrani and Barthwal, {M. S.} and T. Sawant and Andrea Deluca and Nishi Suryavanshi and Geetanjali Chander and R. Bollinger and Golub, {J. E.} and A. Gupta",

note = "Publisher Copyright: {\textcopyright} 2021 The Union",

year = "2021",

month = mar,

day = "1",

doi = "10.5588/IJTLD.20.0778",

language = "English (US)",

volume = "25",

pages = "182--190",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease ",

number = "3",

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TY - JOUR

T1 - Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

AU - Cox, S. R.

AU - Gupte, Akshay

AU - Thomas, B.

AU - Gaikwad, S.

AU - Mave, Vidya

AU - Padmapriyadarsini, C.

AU - Sahasrabudhe, T. R.

AU - Kadam, D.

AU - Gupte, Nikhil

AU - Hanna, L. E.

AU - Kagal, A.

AU - Paradkar, M.

AU - Thiruvengadam, K.

AU - Jain, D.

AU - Atre, S.

AU - Sekar, K.

AU - Raskar, S.

AU - Shivakumar, S. V.B.Y.

AU - Santhappan, R.

AU - Deshmukh, S.

AU - Pradhan, N.

AU - Kulkarni, V.

AU - Kakrani, A.

AU - Barthwal, M. S.

AU - Sawant, T.

AU - Deluca, Andrea

AU - Suryavanshi, Nishi

AU - Chander, Geetanjali

AU - Bollinger, R.

AU - Golub, J. E.

AU - Gupta, A.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - BACKGROUND: Approximately 10% of incident TB cases worldwide are attributable to alcohol. However, evidence associating alcohol with unfavorable TB treatment outcomes is weak. METHODS: We prospectively evaluated men (>18 years) with pulmonary TB in India for up to 24 months to investigate the association between alcohol use and treatment outcomes. Unhealthy alcohol use was defined as a score of >4 on the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) scale at entry. Unfavorable TB treatment outcomes included failure, recurrence, and all-cause mortality, analyzed as composite and independent endpoints. R E S U LT S: Among 751 men, we identified unhealthy alcohol use in 302 (40%). Median age was 39 years (IQR 28-50); 415 (55%) were underweight (defined as a body mass index [BMI],18.5 kg/m2); and 198 (26%) experienced an unfavorable outcome. Unhealthy alcohol use was an independent risk factor for the composite unfavorable outcome (adjusted incidence rate ratio [aIRR] 1.47, 95% CI 1.05-2.06; P¼0.03) and death (aIRR 1.90, 95% CI 1.08-3.34; P¼ 0.03), specifically. We found significant interaction between AUDIT-C and BMI; underweight men with unhealthy alcohol use had increased risk of unfavorable outcomes (aIRR 2.22, 95% CI 1.44-3.44; P, 0.001) compared to men with BMI >18.5 kg/m2 and AUDIT-C,4. CONCLUSION: Unhealthy alcohol use was independently associated with unfavorable TB treatment outcomes, highlighting the need for integrating effective alcohol interventions into TB care.

AB - BACKGROUND: Approximately 10% of incident TB cases worldwide are attributable to alcohol. However, evidence associating alcohol with unfavorable TB treatment outcomes is weak. METHODS: We prospectively evaluated men (>18 years) with pulmonary TB in India for up to 24 months to investigate the association between alcohol use and treatment outcomes. Unhealthy alcohol use was defined as a score of >4 on the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) scale at entry. Unfavorable TB treatment outcomes included failure, recurrence, and all-cause mortality, analyzed as composite and independent endpoints. R E S U LT S: Among 751 men, we identified unhealthy alcohol use in 302 (40%). Median age was 39 years (IQR 28-50); 415 (55%) were underweight (defined as a body mass index [BMI],18.5 kg/m2); and 198 (26%) experienced an unfavorable outcome. Unhealthy alcohol use was an independent risk factor for the composite unfavorable outcome (adjusted incidence rate ratio [aIRR] 1.47, 95% CI 1.05-2.06; P¼0.03) and death (aIRR 1.90, 95% CI 1.08-3.34; P¼ 0.03), specifically. We found significant interaction between AUDIT-C and BMI; underweight men with unhealthy alcohol use had increased risk of unfavorable outcomes (aIRR 2.22, 95% CI 1.44-3.44; P, 0.001) compared to men with BMI >18.5 kg/m2 and AUDIT-C,4. CONCLUSION: Unhealthy alcohol use was independently associated with unfavorable TB treatment outcomes, highlighting the need for integrating effective alcohol interventions into TB care.

KW - AUDIT

KW - Adverse outcomes

KW - Failure

KW - Mortality

KW - Recurrence

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U2 - 10.5588/IJTLD.20.0778

DO - 10.5588/IJTLD.20.0778

M3 - Article

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AN - SCOPUS:85102905636

SN - 1027-3719

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JO - International Journal of Tuberculosis and Lung Disease

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Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

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Keywords

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