Understanding the molecular basis of palonosetron's long-lasting action

Camilo Rojas

Research output: Contribution to journalArticlepeer-review


In sum, palonosetron's high affinity and allosteric binding capabilities make it a more efficient receptor antagonist in comparison with agents such as ondansetron and granisetron. Moreover, because palonosetron exhibits positive cooperativity with the 5-HT3 receptor, it may be less likely co be displaced by scrotonin. Palonosetron also results in longer-lasting inhibition of 5-HT3 receptor function compared with ondansetron and granisetron. Together with its longer plasma half-life, these differentiating pharmacologic features may rationalize clinical research evaluating the effectiveness of single-dose palonosetron in preventing CINV throughout the delayed phase.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalClinical Advances in Hematology and Oncology
Issue number12 SUPPL. 19
StatePublished - Dec 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology


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