Understanding the molecular basis of palonosetron's long-lasting action

In sum, palonosetron's high affinity and allosteric binding capabilities make it a more efficient receptor antagonist in comparison with agents such as ondansetron and granisetron. Moreover, because palonosetron exhibits positive cooperativity with the 5-HT₃ receptor, it may be less likely co be displaced by scrotonin. Palonosetron also results in longer-lasting inhibition of 5-HT₃ receptor function compared with ondansetron and granisetron. Together with its longer plasma half-life, these differentiating pharmacologic features may rationalize clinical research evaluating the effectiveness of single-dose palonosetron in preventing CINV throughout the delayed phase.