Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation

Jessica Queen; Fyza Shaikh; Cynthia L. Sears

doi:10.1038/s43018-023-00602-2

Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation

Jessica Queen, Fyza Shaikh, Cynthia L. Sears

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.

Original language	English (US)
Pages (from-to)	1083-1094
Number of pages	12
Journal	Nature Cancer
Volume	4
Issue number	8
DOIs	https://doi.org/10.1038/s43018-023-00602-2
State	Published - Aug 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/s43018-023-00602-2

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title = "Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation",

abstract = "The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.",

author = "Jessica Queen and Fyza Shaikh and Sears, {Cynthia L.}",

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year = "2023",

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AB - The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.

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Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation

Abstract

ASJC Scopus subject areas

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