Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

P. Darrell Neufer; Marcas M. Bamman; Deborah M. Muoio; Claude Bouchard; Dan M. Cooper; Bret H. Goodpaster; Frank W. Booth; Wendy M. Kohrt; Robert E. Gerszten; Mark P. Mattson; Russell T. Hepple; William E. Kraus; Michael B. Reid; Sue C. Bodine; John M. Jakicic; Jerome L. Fleg; John P. Williams; Lyndon Joseph; Mary Evans; Padma Maruvada; Mary Rodgers; Mary Roary; Amanda T. Boyce; Jonelle K. Drugan; James I. Koenig; Richard H. Ingraham; Danuta Krotoski; Mary Garcia-Cazarin; Joan A. McGowan; Maren R. Laughlin

doi:10.1016/j.cmet.2015.05.011

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

P. Darrell Neufer, Marcas M. Bamman, Deborah M. Muoio, Claude Bouchard, Dan M. Cooper, Bret H. Goodpaster, Frank W. Booth, Wendy M. Kohrt, Robert E. Gerszten, Mark P. Mattson, Russell T. Hepple, William E. Kraus, Michael B. Reid, Sue C. Bodine, John M. Jakicic, Jerome L. Fleg, John P. Williams, Lyndon Joseph, Mary Evans, Padma MaruvadaMary Rodgers, Mary Roary, Amanda T. Boyce, Jonelle K. Drugan, James I. Koenig, Richard H. Ingraham, Danuta Krotoski, Mary Garcia-Cazarin, Joan A. McGowan, Maren R. Laughlin

Research output: Contribution to journal › Article › peer-review

189 Scopus citations

Abstract

The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps in knowledge and potential strategies for catalyzing progress in the field, the NIH convened a workshop in late October 2014 entitled "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits." Presentations and discussions emphasized the challenges imposed by the integrative and intermittent nature of PA, the tremendous discovery potential of applying "-omics" technologies to understand interorgan crosstalk and biological networking systems during PA, and the need to establish an infrastructure of clinical trial sites with sufficient expertise to incorporate mechanistic outcome measures into adequately sized human PA trials. Identification of the mechanisms that underlie the link between PA and improved health holds extraordinary promise for discovery of novel therapeutic targets and development of personalized exercise medicine.

Original language	English (US)
Pages (from-to)	4-11
Number of pages	8
Journal	Cell Metabolism
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2015.05.011
State	Published - Jul 7 2015
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Physiology

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Neufer, P. D., Bamman, M. M., Muoio, D. M., Bouchard, C., Cooper, D. M., Goodpaster, B. H., Booth, F. W., Kohrt, W. M., Gerszten, R. E., Mattson, M. P., Hepple, R. T., Kraus, W. E., Reid, M. B., Bodine, S. C., Jakicic, J. M., Fleg, J. L., Williams, J. P., Joseph, L., Evans, M., ... Laughlin, M. R. (2015). Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits. Cell Metabolism, 22(1), 4-11. https://doi.org/10.1016/j.cmet.2015.05.011

Neufer, PD, Bamman, MM, Muoio, DM, Bouchard, C, Cooper, DM, Goodpaster, BH, Booth, FW, Kohrt, WM, Gerszten, RE, Mattson, MP, Hepple, RT, Kraus, WE, Reid, MB, Bodine, SC, Jakicic, JM, Fleg, JL, Williams, JP, Joseph, L, Evans, M, Maruvada, P, Rodgers, M, Roary, M, Boyce, AT, Drugan, JK, Koenig, JI, Ingraham, RH, Krotoski, D, Garcia-Cazarin, M, McGowan, JA & Laughlin, MR 2015, 'Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits', Cell Metabolism, vol. 22, no. 1, pp. 4-11. https://doi.org/10.1016/j.cmet.2015.05.011

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Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Abstract

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