Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity

Jerry Tsai; Mary Rostom; Luis A. Garza

doi:10.1016/j.jid.2021.06.016

Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity

Jerry Tsai, Mary Rostom, Luis A. Garza

Research output: Contribution to journal › Review article › peer-review

Abstract

Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.

Original language	English (US)
Pages (from-to)	282-284
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	142
Issue number	2
DOIs	https://doi.org/10.1016/j.jid.2021.06.016
State	Published - Feb 2022
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2021.06.016

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title = "Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity",

abstract = "Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.",

author = "Jerry Tsai and Mary Rostom and Garza, {Luis A.}",

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AU - Garza, Luis A.

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N2 - Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.

AB - Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.

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Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity

Abstract

ASJC Scopus subject areas

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