unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans

Brinda Prasad, Ozgur Karakuzu, Randall R. Reed, Scott Cameron

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


unc-3 encodes the Caenorhabditis elegans ortholog of the Olf-1/Early B cell factor family of transcription factors, which in vertebrates regulate development and differentiation of B lymphocytes, adipocytes, and cells of the nervous system. unc-3 mutants are uncoordinated in locomotion. Here we show that unc-3 represses a VC-like motor neuron program in the VA and VB motor neurons, which in wild-type animals control backwards and forwards locomotion, respectively. We identify a physical interaction between UNC-3 and the C2H2 zinc finger transcription factor PAG-3, the mammalian homologs of which are coexpressed in olfactory epithelium and hematopoietic cells. Our data explain the locomotory defects of unc-3 mutants and suggest that interactions between unc-3 and pag-3 orthologs in other species may be functionally important.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalDevelopmental biology
Issue number2
StatePublished - Nov 15 2008


  • Ebf-1
  • Gfi-1
  • Motor neuron fate
  • olf-1
  • pag-3
  • unc-3

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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