Ultrasound can differentiate inclusion body myositis from disease mimics

Kristofoor E. Leeuwenberg, Nens van Alfen, Lisa Christopher-Stine, Julie J. Paik, Eleni Tiniakou, Christopher Mecoli, Jonne Doorduin, Christiaan G.J. Saris, Jemima Albayda

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases. Methods: Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls. Results: Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle. Discussion: Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM.

Original languageEnglish (US)
Pages (from-to)783-788
Number of pages6
JournalMuscle and Nerve
Issue number6
StatePublished - Jun 1 2020


  • diagnosis
  • echogenicity
  • inclusion body myositis
  • neuromuscular disorders
  • quantitative muscle ultrasound

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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