Ultrasensitivity in (SUPRA)molecularly organized and crowded environments

Miguel A. Aon, Diego F. Gomez-Casati, Alberto A. Iglesias, Sonia Cortassa

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.

Original languageEnglish (US)
Pages (from-to)1091-1099
Number of pages9
JournalCell biology international
Issue number11
StatePublished - 2001
Externally publishedYes


  • Crowding
  • Cytoskeleton
  • Metabolic pathways
  • Signalling cascades
  • Ultrasensitivity

ASJC Scopus subject areas

  • Cell Biology


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