Ultrasensitivity in (SUPRA)molecularly organized and crowded environments

Miguel A. Aon; Diego F. Gomez-Casati; Alberto A. Iglesias; Sonia Cortassa

doi:10.1006/cbir.2001.0804

Ultrasensitivity in (SUPRA)molecularly organized and crowded environments

Miguel A. Aon, Diego F. Gomez-Casati, Alberto A. Iglesias, Sonia Cortassa

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.

Original language	English (US)
Pages (from-to)	1091-1099
Number of pages	9
Journal	Cell biology international
Volume	25
Issue number	11
DOIs	https://doi.org/10.1006/cbir.2001.0804
State	Published - 2001
Externally published	Yes

Keywords

Crowding
Cytoskeleton
Metabolic pathways
Signalling cascades
Ultrasensitivity

ASJC Scopus subject areas

Cell Biology

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10.1006/cbir.2001.0804

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title = "Ultrasensitivity in (SUPRA)molecularly organized and crowded environments",

abstract = "The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.",

keywords = "Crowding, Cytoskeleton, Metabolic pathways, Signalling cascades, Ultrasensitivity",

author = "Aon, {Miguel A.} and Gomez-Casati, {Diego F.} and Iglesias, {Alberto A.} and Sonia Cortassa",

note = "Funding Information: This work was supported by a grant from Consejo Nacional de Investigaciones Cient{\'i}ficas y T{\'e}cnicas (CONICET, Argentina, PIP 0443/98) and Agencia Nacional de Promoci{\'o}n Cient{\'i}fica y Tecnol{\'o}gica (ANPCyT PICT{\textquoteright}99 1-6074). D.F.G.C. is a fellow from CONICET; M.A.A., S.C. and A.A.I. are research scientists from the same institution.",

year = "2001",

doi = "10.1006/cbir.2001.0804",

language = "English (US)",

volume = "25",

pages = "1091--1099",

journal = "Cell biology international",

issn = "1065-6995",

publisher = "Portland Press Ltd.",

number = "11",

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T1 - Ultrasensitivity in (SUPRA)molecularly organized and crowded environments

AU - Aon, Miguel A.

AU - Gomez-Casati, Diego F.

AU - Iglesias, Alberto A.

AU - Cortassa, Sonia

N1 - Funding Information: This work was supported by a grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, Argentina, PIP 0443/98) and Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT PICT’99 1-6074). D.F.G.C. is a fellow from CONICET; M.A.A., S.C. and A.A.I. are research scientists from the same institution.

PY - 2001

Y1 - 2001

N2 - The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.

AB - The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.

KW - Crowding

KW - Cytoskeleton

KW - Metabolic pathways

KW - Signalling cascades

KW - Ultrasensitivity

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U2 - 10.1006/cbir.2001.0804

DO - 10.1006/cbir.2001.0804

M3 - Review article

C2 - 11913953

AN - SCOPUS:0035213599

SN - 1065-6995

VL - 25

SP - 1091

EP - 1099

JO - Cell biology international

JF - Cell biology international

IS - 11

ER -

Ultrasensitivity in (SUPRA)molecularly organized and crowded environments

Abstract

Keywords

ASJC Scopus subject areas

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